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Polio Vaccines Given Decades Ago Carried Carcinogenic Virus SV40

Write to Karl Loren -- he will answer

 

Karl Loren Note:  You are going to see more and more headlines on what will be called the "end times."  This biblical reference will be, itself, very common in the religious press, and even in the "conspiracy" circles.  But, the truth is not all in those camps.   There are aspects of truth in those stories, however.

What cannot be denied is that dramatic events, unpredicted and beyond understanding, have occurred in recent years, with an acceleration in recent months.

I have written of terrorism -- which dumped into our consciousness to so change our lives.

The drug culture has been with us for many years, but recently the so-called legal drugs have more and more been exposed as harmful frauds.  Even as psychiatric drugs are on the increase of usage, so are the exposes tumbling out.

We have dozens of "new diseases" which I call "invented diseases" because the doctors don't know what causes them nor how to cure them.  The cure is NOT in the drug field, but much more in the field of morals and diet.  What is AIDS other than a disease of moral corruption -- no matter how much those with AIDS look for a virus as cause.     The virus is NOT the cause of AIDS.

The fall of the Berlin Wall was certainly unexpected, several years ago, but it was one of those "good changes."  The more recent changes are exposes of wrong doing and harm to people.

The much more recent scandal about priest abuse of children -- the harm to the children gets the attention, but the harm to the Church is far greater.  Man, thus, is losing another powerful force for morality.

This page features an article in the Wall Street Journal, below, exposing a US Government sin of more than 40 years ago -- when a polio vaccine was found to be dangerous and the danger was deliberately hidden from the millions of people who kept on getting the vaccine, for years after its dangers were known to "authorities."  The astounding thing about this story is NOT the story itself, but the fact that it has appeared in the Wall Street Journal.  There are other articles on this same page that told the same story -- but they were discounted because they were not published in "respectable" places!

The Chairman of the Federal Reserve Board put a label on another dramatic event -- he calls it the "Infectious Greed" of the American Business World.  Investors have lost literally trillions of dollars in value because of corruption among the very elite of our business world -- the Chief  Executive Officers who take home the multi-million salaries and from whom we had expected, at least, honesty.

I would not call these events the "Endtimes" or the "Last Days" but I can assure you that these phrases are increasingly in use in many religious groups.  I would suggest that we are in for even more dramatic changes in the next few years.

Read here, about the dangerous vaccine poked into the arms of millions of trusting Americans -- and wonder how much they will trust the government when they learn about THIS ONE!


Wall Street Journal Article On Polio Vaccines

Michele Carbone, M.D., Ph.D.

Polio vaccines and the SV40 virus

Simian Virus-40 Contamination of Polio Vaccine and Cancer

Infectious Greed Roiling Business World!

UNDERSTANDING MESOTHELIOMA

  • Mesothelioma and asbestos exposure
  • Differences in pathogenic potential of fibre types
  • Inconsistency in findings of animal and human research
  • Chrysotile, tremolite and mesothelioma
  • Mesothelioma: Who is at risk?
  • Mesothelioma without asbestos exposure
  • VACCINE CONTAMINATION:  GERM WARFARE ON CIVILIANS?


    Source

    The Wall Street Journal  

    July 19, 2002

    SCIENCE JOURNAL
    By SHARON BEGLEY
     

    Polio Vaccines Given Decades Ago Carried Carcinogenic Virus SV40

    Snapshots of your government at work:

    1961.

    The U.S. Public Health Service, having learned in 1960 that millions of batches of polio vaccine were accidentally laced with a simian virus (vaccine was grown on minced monkey kidneys), quietly orders manufacturers to rid the vaccine of the contaminant, called SV40. PHS issues neither recall nor public announcement. Contaminated stocks already distributed are used until 1963.

    1999.

    H.M. Ratner, a former public-health official in Oak Park, Ill., invites Michele Carbone of nearby Loyola University School of Medicine over for coffee. In 1955, Dr. Ratner says, he had refused to administer the Salk polio vaccine.

    He felt it might not be safe. But he kept seven vials in his basement refrigerator for 44 years, hoping that, one day, someone would be interested in them. Someone is. Dr. Carbone is investigating the possibility that SV40-contaminated polio vaccine made by several manufacturers was, decades after being given to about 98 million baby boomers, increasing the risk of three rare cancers.

    2002.

    Last week, the Immunization Safety Review Committee of the Institute of Medicine (IOM) meets to consider evidence for and against that unthinkable hypothesis.

    Amid dueling data, some facts are uncontested. An estimated two-thirds of the polio vaccines -- the oral Sabin and the injected Salk -- administered from 1955 to 1963 contained SV40, including the vials Dr. Ratner saved. Contaminated vaccine was also given to children and some adults in Australia, Canada, Denmark and Germany, and possibly Russia, Mexico and other countries.

    SV40 is a known carcinogen. It targets the lung's mesothelial cells, brain cells, bone cells and blood cells, producing a protein that knocks out two human tumor-suppressor genes, p53 and Rb. There is no reliable blood test for SV40 exposure.

    Government data show the incidence of SV40-linked cancers has risen. A brain cancer called ependymoma is up 25%. Bone malignancies are up 23%. Mesothelioma (infamous for being triggered by asbestos) is up 90%. All are extremely rare: Ependymoma, for example, strikes one in a million.

    Are the rising cancer rates coincidence? In 1994, Loyola's Dr. Carbone and colleagues examined human mesotheliomas. He found SV40 genetic sequences in 29 of 48 studied. SV40 has now been found in up to 80% of mesotheliomas in the U.S. and Europe. Dozens of labs have found SV40 in bone and brain cancers. Those, as I said, are rare. Epidemiologist Howard Strickler of Albert Einstein College of Medicine in New York, a leading skeptic of the vaccine-cancer link, notes that many studies fail to find SV40 in human tumors.

    In March, however, researchers led by Janet Butel of Baylor College of Medicine, Houston, reported that 42% of the non-Hodgkin lymphomas they analyzed contained genetic sequences from SV40. And not just any SV40: In several tumors, it was precisely the genome of the SV40 in the vials of the 1955 polio vaccine that Dr. Ratner had held onto, waiting for someone to care. Lab-grown SV40 harbors a variant genome. There might be other sources, in addition to vaccine, of this strain of SV40, but to more and more scientists Dr. Butel's findings were the smoking gun.

    With Non-Hodgkin lymphoma, we're no longer talking about rare malignancies. This cancer has spiked 82% in the U.S. since 1973, epidemiologist Susan Fisher of the University of Rochester, New York, told the IOM panel, with 56,200 new cases in 2001 and 24,000 deaths.

    An analysis by Dr. Strickler shows no extra cancers among people thought to have been exposed to SV40-laced polio vaccine -- or, no extra increase that can't be explained by chance. Trouble is, with no test for SV40 exposure, it's impossible to be sure you're comparing an exposed to an unexposed group. You might be comparing populations exposed to SV40 with populations also exposed. Of course there'd be no difference.

    What are the ramifications of this? Today's children are at no risk from polio vaccine; it's now grown in SV40-free cells.

    The public-health risk from SV40-laced polio vaccine is ... well, one scientist told me it's "minimal." Another says "unknown." Tumors linked to SV40 are, except for lymphomas, so rare that even a doubling of risk due to SV40 still leaves you with good odds of never developing these cancers.

    A wild card, though, is the World Trade Center collapse, which released asbestos into the air. Although SV40 alone rarely causes mesothelioma, when you add asbestos to the mix, all bets are off. The IOM committee's conclusions on SV40, polio vaccine and cancer are due out by the end of summer.

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    Updated July 19, 2002 12:40 p.m. EDT
     

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    Source

     

     Michele Carbone, M.D, Ph.D.  
      We are studying the simian virus 40 (SV40) and its relationship to human tumors.

     

    Michele Carbone, M.D., Ph.D.
    Assistant Professor of Pathology
    Ph.D.,  Human Pathology
    University of Rome "La Sapienza," 1993

     
      Picture  
      Simian virus 40 (SV40) is a DNA monkey virus that induces specific types of tumors when injected into hamsters: ependymomas, mesotheliomas, osteosarcomas and sarcomas.  It has been recently shown that in humans, these same tumor types contain SV40 DNA sequences and express SV40 proteins.
     

    We are currently investigating: 1) The origin of these SV40 sequences in human tumors.  SV40 contaminated polio vaccines until 1963, so we are investigating if these vaccines were the source of SV40 in humans, or whether SV40 has been present in humans prior to the polio vaccines. 2)  The role of SV40 sequences in human tumors.  SV40 might be an innocent bystander, the causative factor, or a co-factor that potentiates the activity of other carcinogens such as asbestos. 3) The possibility of using SV40 as a target for diagnosis and/or therapy. Regardless of the role of SV40 in human carcinogenesis, SV40 proteins present on the surface of tumor cells may represent useful targets for diagnostic or immunotherapeutic approaches.  We are investigating these possibilities by: a) determining if SV40 serves as a marker to confirm the diagnosis of mesothelioma; b) use specific epitopes present on the SV40 large T antigen to elicit a T-cytotoxic immune response against human tumor cells expressing T-antigen.  It is hoped that this experimental approach may lead to the development of a vaccine for SV40-associated tumors.

     

     

     


    UNDERSTANDING MESOTHELIOMA

    Special Report

     


    Mesothelioma, a rare form of cancer of the membranes lining the chest or abdominal cavities, has recently been front and center in the European media. Numerous news reports have alerted the public to forecasts of increases in the number of mesothelioma cases in the coming years. Most of the reports have linked these increased rates to 'asbestos exposure', without differentiating between fibre of product types. In general, only cursory attention has been paid to the large body of scientific evidence that has been accumulating since the 1960s regarding the nature of mesothelioma and its risk factors. 

    CONTENTS

  • Mesothelioma and asbestos exposure
  • Differences in pathogenic potential of fibre types
  • Inconsistency in findings of animal and human research
  • Chrysotile, tremolite and mesothelioma
  • Mesothelioma: Who is at risk?
  • Mesothelioma without asbestos exposure

  • Mesothelioma and asbestos exposure

    The discovery that exposure to certain types of asbestos is linked to pleural mesothelioma is a result of the pioneering work of Dr. Christopher Wagner, who documented the high incidence of the disease amongst people working at or living near crocidolite (blue) asbestos mines as well as in household members of workers at these mines. Later research by Newhouse and Thompson (1965) also found elevated mesothelioma risks amongst workers (and their household members) at a manufacturing plant using crocidolite.

    Generally, once diagnosed, cases of mesothelioma are rapidly fatal, but the very long latency of the disease means that symptoms may only begin to appear 20, 30 or even more than 50 years after initial exposures.

    From the 1940s through to the 1970s, crocidolite and another amphibole, amosite, were used extensively, either alone or in conjunction with chrysotile, in friable insulation applications in the ship-building and construction industries, primarily in North America and Europe. These sprayed-on applications have been discontinued since the 1970s. To a lesser extent, amphiboles were also used in the manufacture of asbestos-cement pipe. In the past, in most of these industries, workers were exposed to extremely high fibre levels. However, what is particularly disturbing is that a number of cases of mesothelioma have been reported in individuals who have had relatively short but intense exposure to amphiboles.

    The discovery of mesothelioma and its association with certain types of asbestos exposure prompted new research programmes, regulatory attention and increased public awareness of the health risks of asbestos.
     


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    Differences in pathogenic potential of fibre types

    The results of human epidemiological studies and lung mineral content analyses demonstrate that amphiboles (crocidolite and amosite) are more strongly associated with mesothelioma than is chrysotile. Comparative analysis of fibre durability and chemical composition are helping to explain the greater toxicity of amphiboles.

    Of the thousands of asbestos-related mesotheliomas reported, virtually all can be directly attributed to exposure to amphiboles. In his widely cited 1988 review of evidence related to mesothelioma causation, Dr. Andrew Churg found that only 53 cases of chrysotile-related mesothelioma had ever been reported from the tens of thousands of workers studied. Of these, ten cases were observed in secondary industry workers for which there was a strong suspicion of amphibole contamination, and 41 cases have occurred in individuals exposed to chrysotile mine dust, which contained traces of the naturally occurring amphibole; tremolite (Churg, 1988).

    Other evidence of the extremely weak association between chrysotile exposure and mesothelioma has been revealed through the cohort study of some 11,000 Québec chrysotile miners born between 1891 and 1920. The last follow-up of this cohort found that only 37 mesothelioma deaths had been identified among 8,000 deaths from all causes (McDonald et al., 1993). No cases were detected in workers with less than two years of exposure.

    In addition, unlike crocidolite mining towns, there has been no indication of environmentally-related mesothelioma in chrysotile mining communities. Also in contrast to amphiboles, the risks to household members of chrysotile workers through non-occupational contact appear to be extremely low, as only 2 or 3 isolated cases allegedly related to this "second hand" exposure have been reported.

    According to Churg, the research data indicates that although chrysotile asbestos can produce mesothelioma in man, the total number of such cases is small and the required doses extremely large. Another important factor is that while in general, amphiboles have been shown to cause lung disease and cancer after short but intense exposures, chrysotile-related illness is associated with very high, long-term exposures only.


    Greater toxicity of amphiboles linked to durability in the lung
    The greater durability of amphiboles compared to chrysotile appears to be one of the principle reasons for their greater carcinogenic potential. Many researchers now believe that the longer a foreign substance persists in the body, the more likely it is to cause cellular damage and lead to accelerated cell reproduction and chromosomal damage, which are associated with tumour growth. Contrary to chrysotile fibres, which dissolve relatively quickly, amphiboles persist at sites of tumour development and serve as the stimulus for neoplastic (new tissue) growth (Jaurand, 1979; 1984). Because of chrysotile's rapid dissolution, particularly under conditions of low to moderate exposure, it may not persist in the human body over the extended period necessary for the development of tumours.

    Several studies published in the early 1980s were conducted on lung tissue samples from workers whose deaths were considered to be asbestos related and compared to those of control groups. The results showed that the concentrations of amphiboles in their lungs were up to 100 times greater than those found in the control groups - while the amounts of chrysotile observed were similar for the subjects and the controls. Further-more, in asbestotic cases, the amounts of amphiboles, but not of chrysotile, related well quantitatively to the severity of the disease. These differences in biopersistence, according to fibre type, were particularly striking in cases of mesothelioma. For instance, several studies have shown that the mesothelioma cases are correlated with vastly increased lung burdens of amphiboles, but not chrysotile.

    The most recent data available on the retention of asbestos fibres in lung tissue of asbestos workers is a Swedish study which shows different kinetics for amphibole and chrysotile fibres in human lung tissue (Albin et al., 1994). Amphibole fibre concentrations increase with duration of exposure, whereas chrysotile concentrations do not. Furthermore, the authors indicate that their study supports a former finding of a possible adaptive clearance of chrysotile, and conclude that it "support the hypothesis that adverse effects are associated rather with the fibres that are retained (amphiboles), than with the ones being cleared (largely chrysotile)."


    Amphiboles, iron and oxygen radicals
    In addition to the longer biopersistence of amphiboles, their iron-content particles appears to trigger an oxidative stress process - the generation of "Active Oxygen Species" (AOS), which some researchers believe can cause membrane damage, induce the release of inflammatory compounds, which can lead to fibrosis, and even cause DNA strand breaks, which can lead to lung cancer. AOS production is normally held in check by protective agents and scavenger enzyme mechanisms. However, it is believed that high and sustained generation of AOS can eventually overwhelm scavenger mechanisms and lead to 'oxydative lung injury.'

    Thus, studies of the impact of chemical composition on the carcinogenicity of fibrous materials have been undertaken. Iron-containing particles can produce AOS by oxidizing their iron (Guilianelli et al., 1993). Brooke Mossman, of the University of Vermont College of Medicine, suggests that the lower amounts and bio-availability of iron in chrysotile fibres may render them less biologically active over time. Other studies have confirmed the importance of fibre length and geometry in the generation of AOS by alveolar macrophages. Longer fibres such as crocidolite and erionite have been found to generate larger amounts of AOS, whereas short fibres and particles are generally relatively inactive (Hansen & Mossman, 1987).

    Albin A, Pooley FD, Strömberg U, Attewell R, Mitha R and Welinder H, (1994) Retention patterns of asbestos fibres in lung tissue among asbestos cement workers. Occup. Environ. Med., 51: 205- 211.

    Churg, A. (1988) Chrysotile, Tremolite, and Malignant Mesothelioma in Man. Chest, 93: 621-628.

    Guilianelli, C et al. Effect of Mineral Particles Containing Iron on Primary Cultures of Rabbit Trachael Epithelial Cells: Possible Implication of Oxidative Stress. Env. Health Persp., 1993; 101.

    Hansen, K, Mossman, BT. Generation of superoxide from alveolar macrophages exposed to asbestiform and non-fibrous particles. Cancer Res. 1987;47:1681-6.

    Jaurand, MC, Bignon, J, Sebastien, P, & Goni, J. Leaching of chrysotile asbestos in human lungs. Correlation within vitro studies using rabbit alveolar macrophages. Envir. Res. 1979; 14:245-54.

    Jaurand, MC, Gaudichet, A, Halpern, S & Bignon, S. In Vitro biodegradation of chrysotile fibres by alveolar macrophages and mesothelial cells in culture: comparison with a pH effect. Br. J. Ind. Med. 1984;41:389-95.

    McDonald, JC, Liddell, FD, Dufresne, A and McDonald, AD. The 1891-1920 birth cohort of Quebec chrysotile miners and millers: mortality 1976-88. Br. J. Ind. Med., 1993;60:1073.

    Wagner, JC, Slegges, CA and Marchand, P. (1960) Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Brit. J. Ind. Med. 17:260-271.


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    Inconsistency in findings of animal and human research

    Past animal studies comparing chrysotile and amphiboles have failed to confirm epidemiological findings of the stronger association between amphiboles and mesothelioma. A review of experimental protocols used demonstrates why.

    Up until recently, most studies published in the field of animal experimentation, following administration of different asbestos fibre types by inhalation or injections, have not identified significant differences in the pathogenic potential of the various asbestos fibre types. The reported effects were not consistent with epidemiological observations indicating that amphibole fibres are markedly more potent than chrysotile in inducing asbestosis, lung cancer and mesothelioma. However, in many of these studies, the comparisons of effects (fibrogenicity and tumor yield) has been based on gravimetric measures: that is, using mass as the means defining the dose of the tested minerals.

    The use of fibre mass rather than fibre number in animal studies has resulted in an overstatement of the health effects of chrysotile compared to other fibres. It is widely known that similar masses of chrysotile and amphiboles or other mineral fibres can vary significantly in fibre number. For example, for fibres longer than 8 microns, the number of fibres per mg of chrysotile may be up to 100 times higher than that for crocidolite (Palekar et al., 1988).

    In fact, attempts to transform gravimetric doses into fibre numbers have indicated that fibre for fibre, chrysotile is less pathogenic than the amphibole varieties. More recently, studies using both fibre mass and fibre number as units of dose have confirmed that amphiboles are more pathogenic than chrysotile. The in vitro models of Yegles et al. (1993) and of Heintz et al. (1993) and the inhalation experiments of McConnell et al. (1994) all support this finding.

    Another important factor in the apparent inconsistency between human and animal data is that inadequate measures have been applied to control for the fibre dimensions of the different substances being tested. Fibre length and diameter are now recognized as extremely important determinants of the fibrogenic and carcinogenic potential of a given substance.

    Heintz NH, Janssen YM and Mossman BT. (1993) Persistent induction of c-fos and c-jun expression by asbestos. Proc. Natl Acad. Sci. 90: 3299-3303.

    McConnell EE, Chevalier HJ, Hesterberg TW, Hadly JG and Mast RW. (1994) in ILSI Monograph "Toxic and carcinogenic effects of solid particles in the respiratory tract", eds. DL Dungworth, JL Mauderly and G. Oberdörster, ILSI Press, pp. 461-467.

    Palekar LD, Most BM & Coffin DL. (1988) Environ. Res., 46:142-152.

    Yegles M, St-Etienne L, Renier L, Janson X and Jauran MC. (1993) Induction of metaphase and anaphase abnormalities by asbestos fibers in rat pleural mesothelial cells in vitro. Amer. J. Resp. Cell. Mol. Biol.9: 186-191.


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    Chrysotile, tremolite and mesothelioma

    Although it has been demonstrated that there is a very weak association between chrysotile exposure and mesothelioma, the presence of occasional fibrous tremolite, an amphibole mineral, in some chrysotile ore body has been cited as a potential risk factor amongst chrysotile workers. The available evidence, however, shows that mesotheliomas in chrysotile mining populations are extremely rare relative to rates in amphibole-exposed populations. In fact, less than 40 mesothelioma cases over several decades have been reported amongst chrysotile miners and millers (McDonald et al. 1993).

    In their analysis of the implications of the 37 mesothelioma cases identified up until 1992 in the 11,000 person cohort, McDonald & McDonald (1995) found that they were concentrated in workers from specific areas of the mines. Further post-mortem lung tissue analysis showed that workers in these areas had tremolite lung content four times higher than those workers in other areas of the mines studied, suggesting that the rare cases of mesothelioma among chrysotile miners are mainly, if not wholly, due to tremolite exposure.

    The authors note that it should be kept in mind that these mesothelioma cases occurred as a result of long, heavy exposures 20 to 70 years ago. They conclude: "The geological distribution of tremolite within the Québec chrysotile ore body may well vary in time and place and, at present levels of environmental controls, any mesothelioma risk from exposure (...) would be far below the limits of epidemiological detection."

    The previous review by Dr. Andrew Churg, a pathologist at the University of British Colombia in Canada, supports this conclusion. Churg (1988) writes, "whether tremolite or chrysotile be the critical agent, these observations suggest that chrysotile ore, in both crude and processed forms, does cause mesothelioma in man, but that it is an extremely weak carcinogen and that in today's terms, the doses required are extremely high. As a practical matter, the data indicate that chrysotile will not produce mesotheliomas in those exposed to any current or recently regulated number of fibers..."

    Churg, A. (1988) Chrysotile, Tremolite, and Malignant Mesothelioma in Man. Chest 93: 621-628.

    McDonald, JC and McDonald, AD (1995) Chrysotile, Tremolite, and Mesothelioma. Science 267: 776-777.


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    Mesothelioma: Who is at risk?

    Reports of persisting incidence of mesothelioma cases despite the fact that most countries have banned the use of amphiboles and sprayed-on applications has sparked concern over the safety of present-day workers. Epidemiological evidence is helping to identify exactly what populations have been at risk and under what conditions.


    Past exposures and the latency effect
    The long latency period of mesothelioma means that it will take several decades before the impact of lower amphibole exposures begins to be seen. Therefore, current cases are related to the legacy of past misuse. The 30, 40 and even 50 year latency period has unfortunately ensured that we will continue to witness the effects of this misuse until early into the next century. The very legitimate question which is now being raised is: How can we be sure that these rates will indeed drop in the future?

    The fact that amphiboles have been banned in almost all countries and sprayed-on applications discontinued years ago, suggests that the conditions giving rise to asbestos-related mesotheliomas we are witnessing today have in large measure been eliminated. To ensure a rapid decline in mesothelioma rates beyond the year 2010, a number of challenges must be met. Firstly, measures need to be taken to prevent dangerous levels of exposure to amphibole asbestos from work with in-place friable insulation materials. Secondly, those few countries, which have not yet discontinued the use of amphibole asbestos, must be encouraged to do so - particularly given that the necessary technology is well known and readily available.


    Minimizing amphibole exposure from in-place insulation materials
    Numerous studies and reports have concluded that at the levels of exposure generally found in buildings with intact asbestos insulation materials, occupants are not at risk. However, workers who may come into frequent and direct contact with these materials need to be protected. The potential for mesothelioma induction after relatively short, intense exposures to amphibole varieties has raised a red flag amongst industrial hygienists who are justifiably concerned over the risks to building construction and maintenance workers, employees involved in ship renovation or demolition work, and any other categories of workers who may come into regular contact with amphiboles or amphibole-containing materials.

    It will take a concerted effort, at several levels, to ensure that exposures are controlled to the extent that no new cases of amphibole-related mesothelioma develop. Most importantly, building owners should be required by law to verify whether their buildings contain friable asbestos insulation materials and if so, put in place a comprehensive management programme, which includes survey and assessment procedures, a plan for instituting corrective measures, and education and training for custodial workers.

    For renovation and demolition work, the law should also require that the competent authorities be notified and that only qualified contractors and workers be hired to perform the work. Regular air monitoring should be carried out to monitor the efficiency of preventive and control measures.


    The need to inform and enforce
    Today, current regulations in most countries provide an adequate framework for controlling mesothelioma risks. However, regulations alone do not guarantee safe work environments. Awareness campaigns targetted at building owners, removal contractors, custodial and maintenance workers will be important. However, to ensure worker health and safety, governments must act to strictly enforce regulations, and in the event of non-compliance, impose meaningful fines and penalties on those found to be in violation. Only in this way will there be assurance that asbestos-related mesothelioma will become a disease of the past.


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    Mesothelioma without asbestos exposure


    For a time, mesothelioma was thought to be exclusively related to asbestos, but more recent reviews indicate that a significant number of cases have occurred in the absence of any known asbestos exposure.

    Although the association between amphibole asbestos and mesothelioma is indisputable, fewer than 10% of the people exposed to asbestos develop mesothelioma, and fiarly large proportions (up to 50% according to some authors) of the reported cases have no documented exposure to asbestos.

    A comprehensive survey of adult mesothelioma cases in Canada and the U.S. carefully classified patients based on their likelihood of past exposure to asbestos. The researchers found that asbestos exposure had been unlikely in between 1/4 and 1/3 of cases (McDonald & McDonald, 1980).

    While it is well documented that asbestos-induced mesothelioma has a latency of 20 years or more, a number of studies have highlighted pleural and pericardial mesotheliomas in children as young as 1-1/2 years old (Lemesch et al., 1976). Surveys of reported mesotheliomas in the U.S., Canada and Israel found a combined total of more than 110 cases in persons under the age of 20.

    In addition to these unexplained cases of mesothelioma, a number of other fibrous and non-fibrous materials have been associated with mesothelioma induction. It is now generally accepted in the scientific community that durable, long and thin fibres have fibrogenic and carcinogenic potential. A number of natural and man-made fibres with these characteristics have been established as the cause of mesothelioma in laboratory animals. These include glass fibres, aluminum oxide, attapulgite, dawsonite, silicon carbide and potassium titanate (Stanton et al., 1977).

    The reported outbreak of mesothelioma in rural Turkey has been associated with exposure to fibrous zeolite found in these regions. In his 1980 report, Baris had identified 185 cases of erionite/zeolite-related mesothelioma in two areas of Turkey with no local asbestos deposits or industry.

    Several non-fibrous agents, both organic and inorganic, have also been shown to induce malignant mesothelioma. For example, a causal link between mesothelioma and radiation has been established based on numerous case reports of mesotheliomas developing at the exact sites of radiation therapy. Other suspected causes include biogenic silica fibres, chronic irritation stemming from tuberculosis and other factors, and heavy metals such as beryllium.

     

    Polio vaccines and the SV40 virus

    More recently, it has been reported that a virus (SV40) contaminating some polio vaccine preparations may well be associated with mesothelioma, as some DNA sequences of the virus are sometimes found in cancerous mesothelial cells. These vaccine preparations had been produced in 1954, some eight years before SV40 was first isolated, and had been prepared by growing polio virus in cell cultures from rhesus monkey kidney cells. As a result, millions of people have been injected with SV40-contaminated polio vaccines.

    Recent findings by Dr. M. Carbone and colleagues of the Dept. of Pathology at the University of Chicago and by co-workers at the National Cancer Institute first indicated that the SV40 virus, which induces mesothelioma in hamsters, is also oncogenic for humans. Later on, they found SV40-like DNA sequences in human mesothelioma cases (Carbone et al., 1994). Similar evidence is now beginning to appear from France and the U.K.

    Recent evidence of the significance of the SV40 virus and other potential sources of mesothelioma, suggests that factors other than asbestos exposure may have played a role in recently reported mesothelioma cases in Europe in which the victims are reported to have had only casual, low level contact with asbestos-containing products.

    Baris YI, Artvinli M and Sahin AA. Environmental mesothelioma in Turkey. Ann. NY. Acad. Sci., 1979; 330:423-432.

    Carbone et al.. Oncogene, 1994; 9:1781-1790.

    Lemesch C, Steinitz R and Wassermann M. Edipemiology of mesothelioma in Israel. Environ. Res., 1976; 12:255-261.

    Pelnar PV. Non-asbestos related malignant mesothelioma. Canadian Asbestos Information Centre, 1983.

    Stanton MF and Wrench C. Mechanisms of mesothelioma induction with asbestos and fibrous glass. J. Natl. Cancer Inst., 1972 (March); 48(3):797-821.


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    MEETING SIX
    Simian Virus-40 Contamination of Polio Vaccine and Cancer


    The sixth meeting of the Immunization Safety Review Committee was held July 11-12, 2002 in Washington, DC. On July 11th, the meeting was open to the public. The topic of this meeting was the possible association between Simian Virus-40 (SV40) Contamination of Polio Vaccine and Cancer. The meeting was part of the information gathering process of the committee.


     


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    VACCINE CONTAMINATION:

    GERM WARFARE ON CIVILIANS?

    by Roger G Mazlen

    An excerpt from: Nexus Magazine June/July 1998


    Dr Leonard Horowitz suggests that the widespread incidence of weird cancers and auto-immune illnesses of today is a result of large populations being inoculated with vaccines known by health authorities to be contaminated.

     

    An interview with Leonard G. Horovitz. DMD, MA, MPH by Roger G Mazlen

    Dr Roger G. Mazlen: We have as our guest Dr. Leonard Horowitz, a Harvard graduate, independent investigator and internationally known authority on public health education, who's the author or the best-selling book

    Emerging Viruses:AIDS and Ebola

    Why are we talking to Dr. Horowitz? Simply chronic fatigue syndrome (CFS) patients have a depressed immune system. They have immune deficiency. They have immune suppression. They are sitting ducks for any kind of new viruses, especially those with the ability to destroy the immune system. So, without further ado, welcome to the show Dr. Horowitz.

    Dr Leonard G Horowitz: Thank you, Dr Mazlen. It's a great privilege and pleasure to be with you.

    Dr Mazlen: Well, we're delighted that we're able to talk to you today. Let me let you start by introducing us to the general scope of your book.

    Dr Horowitz: Well, I spent three years investigating a 1970 Department of Defense appropriations request for US $10 million into a five-year study to develop immune-system-ravaging micro-organisms for germ warfare. I didn't believe at first that this was a legitimate document. Ultimately I tracked the money following a paper trail of scientific literature and government documents and I found that the money had gone to an organisation called Litton Bionetics. Did you ever hear of Litton microwave ovens.

    Dr Mazlen: Surely.

    Dr Horowitz:Well, they're also a subsidiary of a megamilitary weapons contracting firm and they had a medical subsidiary which was called Litton Bionetics. They were sixth on the list with major army biological weapons contractors during the late '60s and early '70s. And they commuted numerous immune-system-ravaging micro-organisms for germ warfare. They were the recipients of over US$2 million a year to develop these types of micro-organisms, not only for biological weapons research and development but also for cancer research and vaccine research and development. So, that's basically the book. Emerging Viruses: AIDS and Ebola goes into who made these types of viruses - the AIDS-like, Ebola-Like viruses - how they made them, virtually every step of the way and why they made them. And then, most incredibly, I found and reprinted in black and white the US Government contracts which show you how much US taxpayers pay to finance these research efforts.

    Dr Mazlen: Well, of course, this is a very serious concern to our listening audience - those who have chronic fatigue, or those who suspect they may have, or those who are not sure - because any new virus or any virus which has the ability to suppress immunity constitutes a major threat to these people and to the general public as well.

    Now, in your book, and I'm going to quote you, on page 134 you say: "Putting all the facts together I now understood how humanly benign DNA monkey viruses, like SV40.... and other common retrovirus vaccine contaminants like SFV, could have, over the period of a few decades, become RNA retroviruses that, through contaminated vaccines, spread to millions of people around the world". Could you amplify that a little bit for the audience?

    Dr Horowtiz: Certainly. The gist of the book and the warning of the book Emerging Viruses: AIDS and Ebola is that we have a Food and Drug Administration (FDA) that does not tell health scientists or health professionals or the public the truth about the contaminated vaccines or the methods by which the vaccines are prepared. For example, the oral polio vaccine is still, to this day, being prepared in contaminated monkey kidney tissues which are bringing with it a variety of not only monkey virus contaminants but also the herpes type viruses, such as simian cytomegalovirus, Epstein-Barr and herpes B, which we know are immune-system-suppressing types of viruses.

    We know also that the vaccine that most plausibly delivered AIDS and possibly even chronic fatigue to the world - since they both broke out in the same year, 1978 - was the 1974 experimental hepatitis B vaccine that was prepared in Merck, Sharpe & Dohme's laboratories, along with support from the Centers for Disease Control and the Food and Drug Administration. We know that this particular hepatitis B vaccine was partly prepared in contaminated monkeys that were shipped by Litton - again, a biological weapons contracting firm for the Department of Defense. And we know for a fact that the moneys from which these vaccines were produced were contaminated. We even have testimonial by the man who created these vaccines to that effect. His name is Dr Maurice Hilleman, and he was Merck, Sharpe & Dohme's leading vaccine developer.

    So they developed these vaccines partly in contaminated animals and then they inoculated them into human beings, and it was therefore an accident waiting to happen that we would have a variety of immune-system-related disorders including weird cancers and weird auto-immune illnesses that we have in epidemic proportions today.

    Dr Mazlen:Well that, of course, brings up a lot of issues, but I want to go back to your book again where you quote an interview with Dr Hilleman by Edward Shorter, PhD (Pages 484 -5), where Hilleman said, "there were 40 different viruses in these vaccines anyway that we were inactivating", and Shorter responded, "But you weren't inactivating the ((SV40, simian virus 40)..." And then Hilleman said, "No, that's right." And he even went on to say, "But yellow fever vaccine had leukaemia virus in it, and you know this is in the days of very crude science."

    So, here we now learn from the very statements they made that not only were there immune-damaging viruses, there were even viruses that could spread leukaemia virus. You do go into this in the book. You talk about cases of T-cell leukaemia. What about that for example? Is there still some risk of that occurring?

    Dr Horowitz: I believe so, Dr Mazlen. I believe that many of these risks still continue to this day. Let me give you an example. Today, the Food and Drug Administration, which we rely upon for both our personal and our children's health and safety, must turn a blind eye to as many as 100 monkey virus contaminants per dose of the oral polio vaccine that we're allegedly by law told we must give our children today. And I say "allegedly" because it's not true. We have spiritual and religious exemptions that you can get, and it is actually voluntary, but they make it seem like you can't go to school or you can't get your children into schools or you can't work in, for example, healthcare settings without getting these vaccine - and that's not the truth.

    But you see, the Food and Drug Administration must turn a blind eye to at least 100 of these contaminants per dose because their hands are tied by proprietary laws and non-disclosure agreements place upon them by the pharmaceutical industry. In other words, they're muzzled by the drug makers. So they can't even tell our scientists the true extent of the contaminations and the risks associated with the vaccines. Therefore, the physicians - who get most of their continuing medical education paid for by the pharmaceutical industry as well - never learn the truth; and subsequently, when they look at patients with running eyes and say that these vaccines are "for your own good", or "for your children's own good", they believe it. And they're just basically brainwashed. They're like cult followers, but they don't even know who their cult leaders are in many cases.

    Dr Mazlen: Well, we certainly don't get any real information on the process of vaccine-making in medical school. I mean, there really isn't anything in the curriculum. I don't remember anything in the curriculum that applies to that whatsoever; and so, as you say, it's a fait accompli. You are just told to do it. It's good and you do it. This changes the whole picture, because in good conscience you wouldn't be giving something if you knew that it was contaminated with something that's detrimental.

    Now we're going to talk a little bit about the work that's been done by W. John Martin and how it fits into this book. Dr W. John Martin, MD, PhD, wrote the foreword to this book and there's a section in it in which Dr Horowitz talks about Martin's experience at the FDA at a time when he was director of the Viral Oncology Branch at the FDA's Bureau of Biologics (now the Center for Biologics, Evaluation and Research) and that he had been informed that there was contamination by simian cytomegalovirus. This is important because Dr Martin has been reporting cases of a stealth virus - a CMV virus, which is in the herpes family - in the Mohave Valley are in Arizona, which has been spreading in every direction and toward the major cities and population centres. I would like it very much if you would comment on this.

    Dr Horowitz: Sure, Dr Mazlen, I'd be happy to. Now this basically comes from personal conversations with Dr Martin. Dr Martin, of course, as you mentioned, wrote the foreword to this book, Emerging Viruses, and he talks about his experience as the Bureau of Biologics vaccine tester and actually in charge of testing humans for vaccine contamination between 1976 and 1980. At one point in the book he cites the fact that there's o reason for these vaccines to continue to be contaminated, that the authorities hold the capacity and the technology to clean them up but yet they don't. Well, I go into detail about the social-political background on that, and I'm not going to go into that on your programme today because we don't have time, but let me give you one example.

    When Dr Martin found some of these foreign viruses, DNA viruses and RNA viruses in the vaccines, he went to his superior at the FDA bureau and said to him: "You know, we've got a problem with these vaccines." And his boss said to him: "stop worrying about it. Every time you eat an apple, you ingest foreign DNA". That was the response.

    Dr Mazlen: That's not too comforting, overall. In fact, it's a comment that leads one to feel a certain sense of insecurity about vaccines, and there have been times when we've had guests on this program who commented about whether or not they should give vaccines to their children or to people with chronic fatigue syndrome. It makes it difficult to counsel them because you're really not sure what's there. Now specifically, Martin also mentions - that the SV40 which was in the oral polio vaccines is actually pretty much carried in the general community and it's spreading.

    Dr Horowitz: Right, and as a matter of fact it was, I think, three weeks ago now when the Journal of the American Medical Association (JAMA) carried the first article showing that the simian virus 40, the 40th monkey virus ever discovered, was known in 1961 to be contaminating both Salk and Sabin polio vaccines and that, in fact, those vaccines had been given to well over 100 million people around the world, mostly in Russia.

    According to Hilleman - we have him on tape, again being interviewed by Shorter - the joke of the day in 1961 became, sine they had just inoculated mostly Russians with this contaminated vaccine, that the Russian athletes were going to come to the next Olympics with tumours.

    Well, you see, they never cleaned them up, not completely, and today, again, we're still getting and we're still giving contaminated monkey viruses to human beings

    The article in JAMA discusses specific types of cancers - "unique cancers", they said - and states that the general public should not be concerned. And I beg to differ with them. I think it should be an extreme concern. I think we should literally have a moratorium on US Government-promulgated vaccines until there is a thorough, independent scientific investigation as well as, hopefully, a congressional investigation into all the documented facts. But the JAMA article said that there were now unique cancers associated with SV40.

    An earlier article talked about 25 per cent of a very large Italian population carrying these monkey viruses in their bodies, and I suspect that it's a larger percentage here in the United States.

    A woman by the name of Bernice Eddy (a doctor of bacteriology)discovered (in 1954, with cancer researcher Sarah Stewart) this particular virus that was first called SE polyoma. She discovered this virus in contaminated polio vaccines, and she took photographs of a dozen monkeys which had keeled over dead and paralysed when she administered the vaccine. Her boss at the NIH confiscated the photos and demoted and defunded her; and then 10 years of crusading later, in 1972, she gets before Congress and she tells the United States Congress people: "If you continue to allow these contaminated vaccines to go out, I guarantee you that over the next 20 years you will have epidemics of cancer unlike the world has ever seen". And that's precisely what we have today.

    Dr Mazlen: Certainly, if you include the AIDS virus as part of this, no doubt. In terms of your research - which is extensive in the book, and I certainly think that anyone who reads it will be impressed by the amount of work you have done - you do go into, at length, the fact that the AIDS virus might have come about through synthetic development, blending a number of killer viruses in an effort to make an immune-destroying virus. When did that happen?

    Dr Horowtiz: This type of research, wherein simian virus 40 and other monkey viruses were used and then mutated or hybridised with other animal cancer viruses, began in the early 1960s. The contracts that are reprinted in Emerging Viruses show that it was February 12, 1962 that the Special Virus Cancer Program began. That was a largely funded, mostly secret program that resulted after the people on the inside at the National Institutes of Health realised they had just inoculated well over 100 million people around the world with cancer-virus-ridden vaccines.

    When they started this, it was kind of like the ground floor of a huge business opportunity at that point, and they began to do extensive research in mutating monkey viruses to see what would produce cancer with them, and then, perhaps, how they might be treated with vaccines and whatever else.

    So, it was in the '60s, and particularly by the late'60s, that researchers at Litton Bionetics - Dr Robert Gallo was overseeing them - and researchers at the National Cancer Institute as well, were very adept at taking monkey viruses and recombining them with things like feline leukaemia virus RNA that caused a whole laundry list of symptoms virtually identical to what AIDS patients suffer from. Another favourite one that they used to mutate monkey viruses with, was the chicken leukaemia sarcoma virus RNA that caused wasting, immunosuppression and death. And then the researchers recorded that to get this type of virus to jump species readily - they cultured it in human white blood cells in some studies and human foetal tissue cells in culture in other studies so that it would adapt - the virus would develop what's called the "attachment apparatus". Those are the unique proteins like the gp120-like protein.

    Dr Mazlen: A couple of very important things I want to say before we have to close the show for today. One, is it safe for people to donate blood if you're not screening for SV40 and simian CMV virus?

    Dr Horowitz: No, I think not. I think that's a very urgent question that should also be addressed by independent scientific investigation and congressional investigation. You see, the blood bankers - the international blood "banksters", as I like to call them - are the people who allowed 10,000 haemophiliacs thoughout the United States to get HIV-contaminated blood. And recently we've been told that if you had a blood transfusion between 1970 and 1990, you'd better go get checked for the cancer ticking-time-bomb virus called hepatitis C. These are the same people who have allowed these types of things. They're very related financially and otherwise to the companies that have been producing the contaminated vaccines. And my concern is that they're making vast fortunes off humanity's suffering through the healthcare system; and people are dying off on this planet. It's interesting that fulfils a very clear and well-articulated, well-documented population reduction agenda. So I'm concerned about those issues.

    Dr Mazlen: We're going to have you back at another time to talk about some of this. Because there's going to be a lot of people who are interested in your book and your research, what number can they reach you at about these things?

    Dr Horowitz: Well, the materials can be gained by called a toll-free number (in the USA). It's 1 888 508 4787. An easy way to remember that number is 1888-50-virus. And I'm pleased to tell you that despite the fact that, over the last year and a half, all the major chain-store buyers have refused to buy the book - in other words, there has been a boycott against the book. It did become a best seller in hardcover about four months ago with the number of sales, but this week Crown Books finally gave us their first order. You could probably go get the book in Crown bookstores today.

    Dr Mazlen: Congratulations on that. I want to ask you, though, are you researching now what's happening with some of these things? The hepatitis B vaccine you implicated might have been contaminated at one point in time. Is it still contaminated?

    Dr Horowitz: Yes, it is. As a matter of fact, I came back from France not too long ago, where I met with one of the top virologists in the world - a cancer virologist who used to work with Gallo and Montagnier. His name is Merko Valjenski, and he basically gave me some scientific documents showing that today's hepatitis B vaccine is still carrying a very carcinogenic enzyme that the authorities have not yet removed.


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