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Relationship between Copper in the Diet and the Aneurysm

Title
Relationship of calcium, magnesium, zinc and copper concentrations in the arterial wall and serum in atherosclerosis obliterans and aneurysm.
Author
Iskra_M; Patelski_J; Majewski_W
Address
(not available)
Source
J Trace Elem Med Biol, 1997 12, 11: 4, 248-52
Abstract
Changes in copper concentration in the arterial wall are important because of cross-linkage formation in collagen and elastin. The breakdown of the elastic layer is characteristic for aneurysm and is affected by the abnormalities in copper metabolism. This study was undertaken to evaluate Ca, Mg, Zn and Cu concentrations and their relationships in the arterial wall, serum and calcified plaque in atherosclerosis obliterans (AO) and abdominal aortic aneurysm (AA). Samples of the aorta wall were obtained at the endarterectomy in AO and the vascular reconstruction in AA. Elements were determined by means of atomic absorption spectrometry. Serum concentrations of Zn and Cu were higher and that of Ca lower in AO as compared to AA and the controls. Arterial concentrations of Zn, Cu and Mg were higher in AO as compared to AA. The ratios of element concentrations in serum (Ca/Mg, Ca/Zn and Mg/Cu) were higher in serum in AA than in AO. Positive correlations were calculated for Ca and Mg (r > or = 0.74), Ca and Zn (r > or = 0.73), Mg and Zn (r > or = 0.90) in the arterial wall in AO and AA. Low but significant correlation was calculated for Cu concentrations between serum and the arterial wall in AA (r = 0.43). Concentrations of Ca, Mg, Zn and Cu were higher in plaque than in the surrounding tissue. The results indicate differences in arterial and serum concentrations of Ca, Mg, Zn and Cu between AO and AA and the accumulation of these elements in the plaque rather than in the surrounding vascular tissue.
Language of Publication
ENG
Unique Identifier
98236389

MeSH Heading (Major)
(none)
MeSH Heading
Adult; Aged; Aged, 80 and over; Endothelium, Vascular | Metabolism; Human; Male; Middle Age; Aortic Aneurysm, Abdominal | Blood; Atherosclerosis | Blood; Calcium | Blood; Copper | Blood; Magnesium | Blood; Zinc | Blood;

Publication Type
JOURNAL ARTICLE
ISSN
0946-672X
Country of Publication
GERMANY
 

 

Title
Alteration of the connective tissue network of striated muscle in copper deficient rats.
Author
Borg_TK; Klevay_LM; Gay_RE; Siegel_R; Bergin_ME
Address
(not available)
Source
J Mol Cell Cardiol, 1985 12, 17: 12, 1173-83
Abstract
The connective tissue network in striated muscle, consisting principally of collagen is arranged in a three dimensional network and is intimately associated with muscle function. Previous studies have shown that animals maintained on a copper-deficient diet undergo myocardial hypertrophy and exhibit cardiovascular lesions such as ventricular aneurysms that eventually rupture. A deficiency of copper in the diet is known to inhibit lysyl oxidase, a metalloenzyme requiring copper as a cofactor and which is also responsible for collagen and elastin crosslinking. Examination by scanning and transmission electron microscopy of skeletal and cardiac muscle from rats maintained on copper-deficient diets showed both gross and microscopic lesions to the connective tissue network. Immunohistochemical staining by light microscopy with antibodies against lysyl oxidase showed that the enzyme was equally present in both control and experimental animals. Fluorescent staining for antibodies against collagen types I and III showed similar results. From these studies we concluded that the collagen secreted during hypertrophy was not crosslinked by lysyl oxidase due to the absence of the copper cofactor. This resulted in the failure of the connective tissue network to transmit and distribute the increased force associated with myocardial hypertrophy and resulted in myocardial aneurysms.
Language of Publication
ENG
Unique Identifier
86115295

MeSH Heading (Major)
(none)
MeSH Heading
Animal; Cholesterol | Blood; Fluorescent Antibody Technique; Histocytochemistry; Male; Microscopy, Electron, Scanning; Myocardium | Analysis; Protein-Lysine 6-Oxidase | Analysis; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Connective Tissue | Analysis; Copper | Blood; Muscles | Analysis;

Publication Type
JOURNAL ARTICLE
ISSN
0022-2828
Country of Publication
ENGLAND

 



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