In 1987, Merck made headlines when it came out with Mevacor (lovastatin), the first cholesterol-lowering statin drug. Statins block enzyme pathways involved in the production of cholesterol, thereby lowering cholesterol levels. But that's not all these drugs do.
The same enzymes that are involved in the production of cholesterol are also required for the production of an essential compound called coenzyme Q10; not surprisingly, lower cholesterol levels in statin users are accompanied by reduced levels of CoQ10.
Coenzyme Q10 -- also called ubiquinone, which means "occurring everywhere" -- plays an important role in the manufacture of ATP, the fuel that runs cellular processes. Though it is present in every cell in your body, it is especially concentrated in the very active cells of your heart. Depriving the heart of CoQ10 is like removing a spark plug from your engine -- it just won't work. Low levels of CoQ10 are implicated in virtually all cardiovascular diseases, including angina, hypertension, cardiomyopathy and congestive heart failure.
WHAT IS MERCK WAITING FOR???
Merck knew that statins deplete CoQ10, and knew that this could contribute to heart disease. In 1990, this drug manufacturer sought and received a patent for Mevacor and other statin drugs formulated with up to 1,000 mg of coenzyme Q10 to prevent or alleviate cardiomyopathy, a serious condition that can cause congestive heart failure. However, Merck has not brought these combination products to market, nor has this drug company educated physicians on the important of supplementing CoQ10 to offset the dangers of these drugs to the heart. Because they hold the patent, other drug companies are prevented from coming out with a statin/CoQ10 product.
If you're taking a statin drug (Zocor, Provacol, etc.), don't wait for your doctor to warn you of the substantial risks. Consider this fact: in the last 15 years (roughly the time that statins have been on the market), the incidence of congestive heart failure has tripled. If you want to avoid becoming a statistic, it is imperative that you take 200 mg of coenzyme Q10 daily. You should also try to lower your cholesterol levels with a low-fat diet, targeted nutritional supplements and exercise.
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